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IGF1R deficiency decreases proliferation, DNA damage, senescence, and vascularization, attenuates tumor invasion by reduced EMT and fibrosis, and induces apoptosis upon pulmonary metastasis To determine the effect of IGF1R deficiency in the metastatic TME, we immunostained lung tumors of LLC-challenged mice for the following markers: Ki67 (proliferation), 53BP1 (DNA damage), p21 (senescence), C3 (apoptosis), CD31 and CD34 (vascularization), SOX9 (epithelial-mesenchymal transition, EMT), as well as Vimentin, Fibronectin, SMA and Masson (fibrosis)

10.1016/j.micres.2024.127824 145 WangJ.LuS.ZhangC.WangJ.WuH.LiG

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As a precautionary measure, it is preferable to avoid use of Acetylcysteine (Fluimucil) during pregnancy

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They can be subdivided according to their properties, dictated by the functional groups they possess